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What medicine stops menstrual bleeding? Medical therapy for menorrhagia may include: Nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs, such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve), help reduce menstrual blood loss. Tranexamic acid. Oral contraceptives. Oral progesterone. Hormonal IUD (Liletta, Mirena).
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